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Mind-altering drugs played key role in rise of Andean civilization

88 points8 hoursscience.org
embedding-shape5 hours ago

> The work also benefits from recent research into the use of hallucinogens in treating mental illness, which has promoted broader acceptance of these substances. “There was long a feeling that drugs made you sick and addicted,” says José Capriles, an archaeologist at Pennsylvania State University (Penn State) who excavates in Bolivia. “Today, there is a new openness,” he adds, which is freeing grant money and attracting graduate students.

I'm really happy to hear things like this. The potential benefits (and drawbacks, of course) been evident to lots of us psychonauts for a long time, and finally the sentiment seems to have turned enough so some money can actually get into the research to see if these things can help us today via treatments. A real joy to see after so many decades of the failed war on drugs that influenced policies across the globe.

GuB-422 hours ago

The problem with psychoactive drugs, as I understand it, is not the lack of positive results. There are plenty of well recognized cases.

The problem is the the unpredictability, because there are plenty of catastrophic results too, and we don't really know why. We can't tell "in your case you should take this dose, the risks are quantified and acceptable, and this is what we should do if things go wrong". And it is not for the lack of trying.

People tend to forget that LSD is a product of "big pharma" and they definitely tried to make a safe and effective treatment out of it, so that they could make money out of their patent.

The "war on drugs" certainly didn't help, but research never really stopped, but we are struggling to turn these drugs into treatments that up to modern standards. And by the way, many controlled substances are used in mainstream medicine: heroin, fentanyl, amphetamines (incl. meth), cocaine, ketamine,...

slowin4 hours ago

It's thought that a lot of the geometric designs in Indigenous pottery and architecture are directly influenced by hallucinogenic plants like datura.

There's a really great YouTube channel called Desert Lore and he covers this topic in depth in this episode. It was really fascinating:

https://youtu.be/Vp4JlUEnPTs?si=j8gH0WnHRpeo1BJu

clickety_clack6 hours ago

Given that many of our current-day subterranean environments are also covered in art and strewn with drug paraphernalia, can we really say that it played a key role in the rise of the civilization?

theplumber4 hours ago

Yeah, like this zombie civilisation: https://m.youtube.com/watch?v=i2k7KQ5L5Jg I am not sure if you can say it’s raising or falling by their posture

fhdkweig2 hours ago

My spidy sense is tingling on this video. The related recommendations on the side include these videos:

In particular it is the thumbnails that look identical.

https://www.youtube.com/watch?v=l6NeLNYCGo0 The Zombies Of America! (i have never seen anything like this..) by Frank van Dam.

https://www.youtube.com/watch?v=snN0PNZVWNA Inside Philadelphia's Real Life Zombie Outbreak by Tyler Oliveira

https://www.youtube.com/watch?v=htZCX1Y0ZiA THE ZOMBIES OF AMERICA (I'VE NEVER SEEN ANYTHING LIKE THIS) by Joe HaTTab

gchamonlive6 hours ago

All you can really say is that negligence is corrosive to civilization, and maybe that drugs act as an amplifier of sorts for society's illnesses and qualities.

boogieknite5 hours ago

could also say a corroded civilization makes vulnerable people feel bad and drugs make them feel good

TimTheTinker4 hours ago

drugs have been making people feel good (and messing with their sense of motivation to behave responsibly) regardless of society's state

dyauspitr6 hours ago

You can 100% say that European civilization was heavily, heavily influenced by the consumption of alcohol.

Gualdrapo6 hours ago

What do you mean "was"?

kekebo6 hours ago

Supposedly there was a time when drinking beer was often safer than drinking water from available sources, including for children. I guess there are levels

onlypassingthru5 hours ago

They didn't make Arnold a saint for nothing.

https://en.wikipedia.org/wiki/Arnold_of_Soissons

AngryData3 hours ago

A lot of it was weaker small beer though too, like 1-2%.

sophacles4 hours ago

Yeah, it's really gross that coffee cups are left all over the place. But yeah, rise in caffeine consumption in place of ethanol is thought to have enabled and fueled the enlightenment, and been a major factor in the industrial revolution.

clickety_clack4 hours ago

I meant the graffiti and needles in tunnels and under bridges etc.

sophacles4 hours ago

I know what you meant. But the words you used apply to my reply too. It's a reminder that any attempt at an objective definition of "drugs" includes alcohol and caffeine, and that there is a huge cultural component to "good drugs" and "bad drugs". In fact, coffee was considered one of the bad drugs by many cultures it when first introduced to them - including European culture.

baxtr6 hours ago

Didn’t mind-altering drugs like alcohol play a key role in the rise of any civilization?

adzm4 hours ago

Alcohol and fermentation have a much different role with food safety and preservation though; the inebriation is just a pleasant side effect for some (and a curse for others)

sophacles3 hours ago

Beer may have lead to the domestication of cereal grains. This is not my theory, here's an article about it: https://nautil.us/beer-domesticated-man-234697

Specifically, we have evidence of beer older than we have evidence of cereal domestication. There is evidence that beer's side effects were considered important for social and religious gatherings (as they are today as well). People wanted to make more beer and so figured out how to plant it. The process to make bread is actually a lot more involved than to make beer and porridge... and porridge just doesn't make as much sense as a motivating factor for domestication when the grains ripen at the same time as many many other easier and tastier foods are also ready in the natural environment.

Arguably, the domestication of grain and invention of agriculture played a role in the rise of many civilizations.

There's no reason to think that humans 10k years ago didn't enjoy getting buzzed, just like humans today do.

dominotw6 hours ago

yes coffee is reason behind our current civilization

cyberpunk5 hours ago

I can't quit it. When I do, after about 2 weeks I completely lose the ability to be a good worker bee and sit in my open plan office,and hide my contempt for the absolute rank ineptitude of almost everyone else there. Load me up with the happy brown juice and I can pretty much make it through. I'm not convinced this is sustainable tbh.

shagie5 hours ago

> ... I completely lose the ability to be a good worker bee ...

Caffeine in Floral Nectar Enhances a Pollinator's Memory of Reward - https://www.science.org/doi/10.1126/science.1228806

> Caffeine improves memory in humans, millions of whom find that their daily dose enhances clarity, focus, and alertness. The human relationship with caffeine is relatively recent, however, and thus its impact on our brains is likely a by-product of its true ecological role. Caffeine occurs naturally in the floral nectar of Coffea and Citrus plants. Wright et al. (p. 1202; see the Perspective by Chittka and Peng) found that caffeine presented at naturalistic levels significantly improved the ability of bees to remember and locate a learned floral scent and potentiated the responses of neurons involved in olfactory learning and memory.

PBS Eons Why Does Caffeine Exist? (5:13 for the bit on bees) - https://www.youtube.com/watch?v=PzshAqowsyI

> In experiments on bees, researchers have found that once they've had a sip of caffeine-laced nectar, it boosts their memory, makes them preferentially revisit the plants, and even helps them pollinate faster and more efficiently. So, for plants, caffeine is a multi-purpose molecule with a lot of adaptive benefits. But, for us, it has one main benefit: it gets us through Monday morning. ...

EMIRELADERO5 hours ago

Chesterton called it, quite fittingly, "The Puritan's opium".

TimTheTinker4 hours ago

And nicotine, don't forget that. Smokers built the modern world (and then developed lung cancer for their troubles).

physicalecon6 hours ago

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LoganDark6 hours ago

Alcohol is a poison, not a drug, but I also think so.

I honestly wish mind-altering drugs were more accessible sometimes, mostly because of safety. Millions are killed by adulterants in their street drugs.

nickff5 hours ago

As the saying goes: “the dose makes the poison”. Many (perhaps most) drugs cause harm at the wrong dosage.

embedding-shape5 hours ago

> Many (perhaps most) drugs cause harm at the wrong dosage.

Not only drugs, almost everything is bad at the wrong dosage. Case in point: water.

LoganDark5 hours ago

Tonicity matters too. Deionized water will suck the ions right out of you. All the way to your death if you're so determined.

quchen5 hours ago

Depending on your definition of poison of course, but at least for LSD and magic mushrooms, all that's known is a lower bound for their biological toxicity. For LSD IIRC it's somewhere in the 30mg (!) range, for mushrooms it's more than can comfortably fit a stomach. I'm afraid I don't have sources handy though.

That said, the state of mind must be so wild that "is it poisonous in this specific/usual sense" is probably not the right thing to discuss.

LoganDark2 hours ago

> That said, the state of mind must be so wild that "is it poisonous in this specific/usual sense" is probably not the right thing to discuss.

I've struggled to tell the difference between doses of LSD that exceed 100µg. Maybe I just take it too frequently to make much of a difference. It's also possible that it only increases duration, but not intensity.

mannanj4 hours ago

So for mold, low enough doses aren't poison? Can't you just say this about anything. If you have poison in a low enough dose it's not poison. So it means jsut about nothing to say alcohol isn't poisonous because you can have a small dose of it.

nickff2 hours ago

Fentanyl is actually much more toxic than the mycotoxins produced by mold (which I'm guessing is what you're referring to), and yet fentanyl is generally recognized to be a useful drug because of its therapeutic effects. If something has no possible therapeutic, recreational, nutritional, or culinary effect, while being toxic, it might be fair to characterize it as a 'pure poison'.

talon86355 hours ago

Poison is a function of dosage. Water is a poison in a high enough dose.

What’s you’re arguments it’s not a drug?

LoganDark5 hours ago

Alcohol requires an astronomical intake compared to most drugs, and I'd say the indiscriminate action and lack of any particular affinity is what makes it a poison as opposed to a drug. It is also generally assumed that alcohol is not exactly in the same category as drugs. ("drugs or alcohol" etc.)

archonis4 hours ago

That's purely because it's usage is accepted nearly as a default, and drug in common usage is most often a pejorative term if it doesn't refer to a medicinal context.

Most people who use drug as a pejorative term also wouldn't use it to describe caffeine.

+1
adgjlsfhk14 hours ago
+1
aeonik4 hours ago
cobbzilla4 hours ago

It’s much more of a poison to some of our primate relatives. iirc the genes that facilitate alcohol metabolism evolved in great apes millions of years before homo sapiens, and we inherited them; we’ve been boozing long before we were even human.

asphodele4 hours ago

if alcohol can damage your short term memory,

Imagine what effect alcohol has

theturtletalks6 hours ago

I read many years ago that psychedelics are what lead to the formation of consciousness. And it’s supported by the fact that psychedelics are also a network like the brain is. And when taking them, your brain experiences plasticity and that’s what allows profound changes.

A big part of our consciousness is the default mode network (which is a default of how we operate day to day, things we think about, etc). Psychedelics allow us to change that DMN, but may it have created it too?

fugalfervor5 hours ago

There is no evidence of that. What you say is not supporting, but rather "conveniently makes sense".

I don't dispute the utility of psychedelics. But I have observed (and this is anecdotal) that the fanatic devotees of the drugs tend to engage in magical thinking around the power/history/whatever of psychedelic substances, no matter their intelligence or accomplishment, or rigorous critical thinking in other areas.

archonis4 hours ago

Reconciling the profound interiority of the experience with a mere external catalyst can be quite challenging.

Consider the question yourself next time you are in the throes of an exoerience and see how hard it is to maintain objectivity...

theturtletalks5 hours ago

It’s a controversial theory, but it does exist[0]. As far as I know, there is no prevailing theory about where consciousness came from so speculating based on existing theories isn’t claiming it’s the truth.

Is it such a leap that fungi are one of the few natural drugs that cause brain elasticity so maybe our early ancestors took it to get the evolutionary process started.

0. https://en.wikipedia.org/wiki/Stoned_ape_theory

robbiep5 hours ago

One of the reasons this is such a long bow to draw is that, as you have absurdly reiterated and an earlier commenter posited, this is Lamarckism. If it is true, where are all the sapient reindeer and other animals that have consumed these substances as a species for as long or longer than we have existed?

talon86355 hours ago

How are psychedelic chemical compounds “a network”? Are you referring specifically to fungal mycelium? Of course there a tons of non psychedelic mushrooms and tons of non-mushroom psychedelics

whakim5 hours ago

There are a number of problems with these statements, but a major one is that psychedelics are associated with reduced activity within the DMN (but increased activity between the DMN and other networks). It is not clear the direction in which this causality runs.

anramon5 hours ago

> psychedelics are what lead to the formation of consciousness

This reads like recycled lamarckism.

nephihaha4 hours ago

"This reads like recycled lamarckism."

Recycled Lamarckianism would be Lysenkoism. :)

plufz6 hours ago

Just for clarification. The default mode network is what activates when we are at rest or ”not focused on the outside world”. Ie daydreaming and mind wandering, even if it also can be active during detailed thinking.

It has also been shown to have negative correlation to networks in the brain associated with attention.

BigTTYGothGF4 hours ago

> I read many years ago that psychedelics are what lead to the formation of consciousness

I have never taken psychedelics but I believe myself to be conscious.

titanomachy6 hours ago

> psychedelics are also a network like the brain is

Sorry to be rude, but what the hell does that mean?

theturtletalks5 hours ago

Fungi grow as a vast interconnected network and can communicate to other fungi. Similarly to how the neurons in the brain communicate.

In fact, when you take fungi, it tones down common neural pathways and allows new ones to form between new places.

titanomachy5 hours ago

Ok, but there are plenty of psychedelics that don't come from fungi.

+1
theturtletalks5 hours ago
474848484 hours ago

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DUDE_LSD_LMAO5 hours ago

[flagged]

LoganDark5 hours ago

Give me enough drugs and I'll create civilization too

dyauspitr6 hours ago

So if you take a lot of psychedelics you end up with a civilization that ritually murders 20,000 people every couple of months.

Just imagine the power you could wield as a shaman with drugs like DMT and psilocybin it would look like a literal magic

TFNA6 hours ago

Are you thinking of the Aztecs or Mayans thousands of kilometers away? Andean human sacrifice involved customs unable to provide that level of throughput.